Vroum Vroum Mag is among 10 entries for the Ladbrokes Boyne Hurdle at Navan on Sunday.
The nine-year-old has not been sighted since finishing lame at the Punchestown Festival in April and retirement had been mentioned for the versatile mare.
Mullins has also entered Augusta Kate, Bacardys, Bapaume and Let's Dance for the Grade Two over two miles and five furlongs.
Gordon Elliott has three possibles in Diamond Cauchois, Lieutenant Colonel and Tiger Roll.
There are nine possibles for the Ten Up Novice Chase, headed by the Elliott four of Jury Duty, Monbeg Notorious, Mossback and Dounikos.
Noel Meade's Moulin A Vent and Mullins' Bonbon Au Miel, C'est Jersey and Livelovelaugh are in the mix, too.
Another possible runner on the card is Elliott's Pallasator in the maiden hurdle, formerly a smart stayer on the Flat with Sir Mark Prescott but only fifth on his hurdling debut behind Next Destination.